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Integrin-linked kinase (ILK) is a multifunctional molecular actor in cell–matrix interactions, cell adhesion, and anchorage-dependent cell growth.
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Integrin-linked kinase is an enzyme that in humans is encoded by the ILK gene involved with integrin-mediated signal transduction. Mutations in ILK are ...
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Conclusion. The combination of genetic, biochemical, and cell biological studies demonstrates that ILK plays a central role in connecting integrins to actin ...
Jan 1, 2005 · Integrin-linked kinase (ILK) is a β1-integrin cytoplasmic domain interacting protein, and functions as a scaffold in forming multiprotein ...
Integrin-linked kinase (ILK) localizes to focal adhesions, and interacts with the cytoplasmic tail of β subunits of integrins and couples them to the actin ...
Apr 15, 2012 · In vivo studies have revealed that ILK is a ubiquitously expressed protein, whose predominant function is to organise the actin cytoskeleton ...
FIGURE 1Functional domains of integrin-linked kinase (ILK). ILK is an intracellular serine/threonine protein kinase with a C-terminal kinase catalytic domain.
May 23, 2011 · Conclusions. The principal argument that ILK is a pseudokinase is based on the primary structure of its atypical protein kinase domain, which ...
Here we show that mice lacking ILK expression die at the peri-implantation stage because they fail to polarize their epiblast and to cavitate. The impaired ...